Translational Neurosciences [Core C]

Director - Laurie Cutting, Ph.D.

About

The Translational Neurosciences Core assists investigators in characterizing brain structure and function in study participants with intellectual and developmental disabilities, in developing magnetic resonance (MR) and EEG/ERP methods, including trans-species MR imaging and physiological studies in mouse models, and in developing tools and approaches to facilitate discovery in IDD.

Core objectives are to assist VKC Investigators in:

  • Design of experiments, including appropriate functional MRI and EEG/ERP/eye tracking tasks and acquisition parameters
  • MR imaging and neurophysiological data collection in various IDDs (especially children and minimally verbal persons)
  • Implementing trans-species MR and EEG/ERP studies
  • Management and analysis of MR and EEG/ERP data
  • Developing analysis pipelines and approaches to address particularly problematic issues in IDD research (e.g., motion artifacts)
  • Facilitating expansion of MR and EEG/ERP methods to generate new IDD research directions
  • Directing large-scale analyses using ImageVU and other data repositories

Services

  • Magnetic Resonance (MR) Imaging

    Includes but is not limited to:
    • Human: Functional MRI (fMRI); Diffusion Imaging (DI); Structural (volumetric) analyses (sMRI), as well as implementation of less routinely used imaging modalities in IDDs (e.g., Magnetic Resonance Spectroscopy; MRS, with expansion planned toMagnetization-Transfer (MT)
    • Animal (IDD mouse models): sMRI and DI, expansion to MRS planned
  • Neurophysiology Measures

    Includes but is not limited to:
    • Human: EEG/ERP, including hyperscanning; eye tracking
    • Animal (IDD mouse models): 2-channel EEG/ERP, with expansion to 30-channel underway

Key Personnel