Translational Neurosciences [Core C]

Director - Laurie Cutting, Ph.D.


The Translational Neurosciences Core assists investigators in characterizing brain structure and function in study participants with intellectual and developmental disabilities, in developing magnetic resonance (MR) and EEG/ERP methods, including trans-species MR imaging and physiological studies in mouse models, and in developing tools and approaches to facilitate discovery in IDD.

Core objectives are to assist VKC Investigators in:

  • Design of experiments, including appropriate functional MRI and EEG/ERP/eye tracking tasks and acquisition parameters
  • MR imaging and neurophysiological data collection in various IDDs (especially children and minimally verbal persons)
  • Implementing trans-species MR and EEG/ERP studies
  • Management and analysis of MR and EEG/ERP data
  • Developing analysis pipelines and approaches to address particularly problematic issues in IDD research (e.g., motion artifacts)
  • Facilitating expansion of MR and EEG/ERP methods to generate new IDD research directions
  • Directing large-scale analyses using ImageVU and other data repositories


  • Magnetic Resonance (MR) Imaging

    Includes but is not limited to:
    • Human: Functional MRI (fMRI); Diffusion Imaging (DI); Structural (volumetric) analyses (sMRI), as well as implementation of less routinely used imaging modalities in IDDs (e.g., Magnetic Resonance Spectroscopy; MRS, with expansion planned toMagnetization-Transfer (MT)
    • Animal (IDD mouse models): sMRI and DI, expansion to MRS planned
  • Neurophysiology Measures

    Includes but is not limited to:
    • Human: EEG/ERP, including hyperscanning; eye tracking
    • Animal (IDD mouse models): 2-channel EEG/ERP, with expansion to 30-channel underway

Key Personnel